11
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4316 | ML365 | Potassium Channel | |
ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3). | |||
T9713 | δ-secretase inhibitor 11 | Beta Amyloid , Caspase | |
δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment. | |||
T26719 | AZD6538 | AZD 6538,AZD-6538 | GluR |
AZD6538 is an mGluR5 negative allosteric modulator used in the study of CNS-related diseases such as Alzheimer's disease. | |||
T9786 | Lu AF27139 | P2X Receptor | |
Lu AF27139 is an effective and selective antagonist of P2X7 receptor (IC50s of 12 and 2.4 nM for human and rat, Kis of 22, 54, and 13 nM for mouse, human, and rat, respectively). Lu AF27139 can be used in CNS diseases st... | |||
T9729 | AGI-43192 | Others | |
AGI-43192 is a potent methionine adenosine transferase 2A (MAT2A) inhibitor that penetrates the blood-brain barrier. AGI-43192 inhibits S-adenosine methionine (SAM) production metabolic enzyme and methionine adenosine tr... | |||
T61025 | GSK-1482160 | P2X Receptor | |
GSK-1482160 is a CNS-penetrant negative allosteric modulator of P2X7 receptor with oral activity. The P2X7 receptor is involved in the production of pro-inflammatory cytokines by central and peripheral immune cells, so G... | |||
T26690 | AVN-101 | 5-HT Receptor , Adrenergic Receptor , Histamine Receptor | |
AVN-101 is a potent 5-HT7 receptor antagonist. | |||
T62517 | S1p receptor agonist 2 | ||
S1p receptor agonist 2 (compound 1) is an agonist of the S1P5 receptor with a higher selectivity than S1P1 and/or S1P3 receptors.S1p receptor agonist 2 can be used in the endogenous SIP signaling system and in the mitiga... | |||
T61073 | KH-259 | ||
KH-259 (compound 1) is a highly potent, selective, and CNS-penetrant HDAC6 inhibitor, demonstrating an IC50 of 0.26 μM. It exerts its antidepressant effects in mice by inhibiting HDAC6 within the brain. Therefore, KH-259... | |||
T79212 | MTOR inhibitor-12 | mTOR | |
mTOR inhibitor-12 (Compound 11), a selective, brain-penetrant mTOR inhibitor, exhibits no genotoxicity risk and is utilized in research pertaining to central nervous system (CNS) diseases [1]. | |||
T81637 | NT-0796 | NOD-like Receptor (NLR) | |
NT-0796, a selective CNS-penetrant NLRP3 inflammasome inhibitor, exhibits potent inhibitory activity with an IC50 of 0.32 nM in PBMC assays. As an isopropyl ester, it is metabolized intracellularly into NDT-19795, its ac... |